Furnari Lab Publications

Parisian, A.D.,Koga, T., Miki, S., Johann, P.D., Kool, M., Crawford, J.R., Furnari, F.B. SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability. ‍Genes and Development, In Press.

He, Y.,Li, J., Koga, T., Ma, J., Dhawan, S., Suzuki, Y., Furnari, F., Prabhu V.V., Allen, J.E., Chen, C.C. Epidermal Growth Factor Receptor (EGFR) as a molecular determinant of glioblastoma response to dopamine receptor 2 (DRD2) inhibitors. Neuro Oncol. In Press.

Ramakrishnan,V., Xu, B., Akers, J., Nguyen, T., Ma, J., Dhawan, S., Ning, J., Mao, Y., Hua,W., Kokkoli, E., Furnari, F, Carter, B.S., Chen, C.C. Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas. ‍EBioMedicine. 55:102736, 2020.

Wang, S., Zhang, Q., Tiwari, S. K., Lichinchi, G., Yau, E.H., Hui, H., Li, W., Furnari, F., Rana, T.  Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy. Cell Rep. 30:969-983,2020.

Koga, T., Chaim, I.A., Benitez, J.A., Markmiller, S., Parisian, A.D., Hevner, R.F., Turner, K.M., Hessenauer, F.M., D’Antonio, M., Nguyen, N.-p. D., Saberi, S., Ma, J., Miki, S., Boyer, A.D., Ravits, J., Frazer, K.A., Bafna, V., Chen, C.C., Mischel, P.S., Yeo, G.W*., Furnari, F.B*.  Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. (*co-corresponding authors).
‍NatureComms. 11:550, 2020.

Wu, S., Turner, K., Nguyen, N., Raviram, R., Erb, M., Santini, J., Luebeck, J., Rajkumar, U., Diao, Y., Li, B.,Zhang, W., Jameson, N., Corces, M., Granja, J., Chen, X., Coruh, C., Abnousi, A., Houston, J., Ye, Z., Hu, R., Yu, M., Kim, H., Law, J., Verhaak, R., Hu, M., Furnari, F., Chang, H., Ren, B., Bafna, V., Mischel, P. Circular extrachromosomal DNA promotes accessible chromatin and high oncogene expression. Nature. 575:699-703, 2019.

Jameson, N.M., Ma, J., Benitez, J., Izurieta, A., Han, J.Y., Mendez, R., Parisian, A., Furnari, F. Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins. Mol Cancer Res.  17:2208-2220, 2019.

Bi, J., Ichu,T.-A., Zanca, C., Yang, H., Zhang, W. Gu, Y., Chowdhry, S., Ikegami, S., Turner, K.M., Zhang, W.,Villa, G.R., Wu, S., Quehenberger, O., Yong, W.H., Kornblum, H.I., Rich., J.N., Cloughesy, T.F., Cavene, W.K., Furnari, F.B., Cravatt, B.F., Mischel, P.S.  Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling. Cell Metabolism.  30: 525-538,2019.

Orellana, L*., Haseley-Thorne, A. Lema, R., Gustavsson, J., Parisian, A., Hospital, A., Brun-Heath, I., Cordeiro, T.N., Bernadó, P., Scott, A.M., Lindahl, E., Cavenee, W*., Furnari, F*., Orozco, M*.  Oncogenic mutations at the EGFR ectodomain share structural convergence to remove a steric hindrance on a kinase-coupled cryptic epitope. (*co-corresponding authors). PNAS. 116:10009-10018, 2019.

Koga, T., Chen, C.C., Furnari, F.B. When less is more: Gaining power through gene rearrangement of amplified EGFR. Oncotarget. In Press.

Chowdhry, S., Zanca, C., Rajkumar, U., Koga, T., Raviram, R., Diao, Y., Liu, F., Turner, K., Yang, H., Furnari, F., Bafna, V., Ren, B., Mischel, P.S.  Tissue lineage determines NAD metabolic dependencies in cancer through gene amplification and epigenetic remodeling. Nature. 569: 570-575, 2019.

Ma, J., Benitez, J.B., Li, J., Miki, S., de Albuquerque, C.P.,  Galatro, T., Orellana, L., Zanca, C., Reed, R., Boyer, A., Koga, T.,Varki, N.M., Fenton, T.R.,  Marie, S.K.N., Lindahl, E., Gahman, T.C., Shiau, A.K., Zhou, H., DeGroot. J., Sulman, E.P., Cavenee, W.K., Kolodner, R.D., Chen, C.C., Furnari, F.B.  Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair. Cancer Cell.  35: 504-518, 2019.

Sun, T., Patil, R., Galstyan, A., Klymyshin, D., Ding, H., Chesnokova, A., Cavenee, W., Furnari, F., Ljubimov, V., Shatalova, E., Wagner, S., Li, D., Mamelak, A., Bannykh, S., Patil, C., Rudnick, J., Hu, J., Grodzinski, Z.,, Rekechenetskiy, A., Falahatian, V., Lyubimov, A., Leoh, L.S., Chen, Y., Daniels-Wells, T., Penichet, M., Holler, E., Ljubimov, A., Black, K., Ljubimova J.  Blockade of a laminin-411 - Notch axis with CRISPR/Cas9 or a nanobioconjugate inhibits glioblastoma growth through tumor-microenvironment crosstalk. Can Res. 79: 1239-1251, 2019.

Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin. Autophogy, 14: 1845-1846, 2018.

Benitez, J.A., Zanca, C., Ma, J., Cavenee, W.K., Furnari, F.B.  Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts. J Vis Exp. 26, 2018.

Binder, Z.A., Thorne, A.H., Bakas, S., Wileyto. E.P., Bilello, M., Akbari. H., Rathore. S., Ha. S.M., Zhang. L., Ferguson. C.J., Dahiya. S., Bi. W.L., Reardon. D.A., Idbaih. A., Felsberg. J., Hentschel. B., Weller. M., Bagley. S.J., Morrissette. J.J.D., Nasrallah. M.P., Ma. J., Zanca. C., Scott. A.M., Orellana. L., Davatzikos. C., Furnari. F.B.*, O'Rourke. D.M.  Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. (* corresponding author and lead contact). Cancer Cell. 34:163-177, 2018.

Koga, T., Li, B., Figueroa, J.M., Ren, B., Chen, C.C., Carter, B.S, Furnari, F.B. Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development. Neuro Oncol. 20: 1310-1320, 2018.

Zanca, C., Villa, G.R., Benitez, J.A., Thorne, A. H., Koga, T., D’Antonio, M., Ikegami, S., Ma, J., Boyer, A.D., Eliseeva, O. V., Barnabe, G.F., Liu, F., Wu, S., Yang, H., Wykosky, J., Frazer, K.A., Verkhusha, V.V., Isaguliants, M.G., Weiss, W.A., Gahman, T.C., Shiau, A.K., Chen, C.C., Mischel, P.S., Cavenee, W.K., Furnari, F.B.  Glioblastoma cellular crosstalk converges on NF-κB to attenuate EGFR inhibitor sensitivity. Genes & Development. 31: 1212-1227, 2017.

Benitez, J.A., Ma, J., D’Antonio. M., Boyer, A.,Camargo, M.F., Zanca, C., Kelly, S.,Khodadadi-Jamayran, A., Jameson, N.M., Andersen, M., Miletic, H., Saberi, S., Frazer, K.A., Cavenee, W.K., Furnari, F.B.  PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nature Comm. 8: 15223, 2017.

Turner, K.M., Deshpande, V., Beyter, D., Koga, T., Rusert, J., Lee, C., Li, B., Arden, K., Ren, B.,  Nathanson, D., Cavenee, W.K., Wechsler-Reya, R., Furnari, F.,Vandenberg, S.R., Rao, N., Wahl, G.M., Bafna, V., Mischel, P.S. Extrachromosomal oncogene amplification drives tumor evolution and the development of genetic heterogeneity in human cancer. Nature. 543: 122-125, 2017.