Frank Furnari Laboratory
About the research
Dr. Furnari
Frank Furnari, Ph.D.
Professor - Department of Medicine
Division of Regenerative Medicine
Moores Cancer Center
Member and Head Laboratory of Tumor Biology
Ludwig Institute for Cancer Research
Contact: ffurnari@ucsd.edu
About the Lab
The primary focus of the Furnari lab research is to study fundamental pathways that drive initiation and progression of glioblastoma, as well as the malignant phenotypes of this aggressive brain cancer, ranging from tumor biology, biochemistry, cell biology, signal transduction and bioinformatic analyses, to orthotopic glioma models and preclinical investigations. Our program has the following main objectives with the overarching goal of molecularly understanding and eradicating glioblastoma and other types of brain cancer:
Tumor heterogeneity: How expression of amplified extracellular domain mutants of the epidermal growth factor gene (EGFR) enhance tumor aggressiveness and promote therapeutic resistance
Tumor vulnerabilities and genetic dependencies: Identifying therapeutically actionable targets
Brain tumor models: Engineering of next generation tumor models that accurately recapitulate the spectrum of subtype driver mutations and the evolution of adult and pediatric brain tumor
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Our People
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Lab Opportunities
The Furnari Lab Brain Cancer Research Fund
To support the Furnari Lab's goal to understand glioblastomas at a molecular level and to eradicate them, as well as other types of brain cancer