Qingfei Jiang Laboratory
About the research
DR. JIANG |
Dr. Qingfei (Fay) Jiang is a cancer stem cell biologist who studies the process of DNA and RNA editing normal and cancer stem cells. She is interested in how these enzymes control cellular processes and gene regulation in specific cell types, and if we can utilize this understanding to better treat cancer patients. She is currently an Assistant Professor of Medicine in the Division of Regenerative Medicine at the University of California, San Diego.
Dr. Jiang received her Ph.D. in chemistry at the University of Southern California, where she worked on DNA damage repair and translation synthesis. She later joined University of California, San Diego in 2010 as a postdoctoral fellow in Dr. Catriona Jamieson’s lab. She conducted research on the role of inflammation-driven A-to-I RNA editing in leukemia stem cell generation using chronic myeloid leukemia (CML) as a model. Dr. Jiang has published several high-impact papers in top tier journals including Nature, Cell Stem Cell, Cancer Cell, PNAS, Nature Communication, and Nature Reviews Cancer. She has also received multiple prestigious awards, the most recent are NCI K22 Career Development Award, and the 2020 Hartwell Individual Biomedical Research Award.
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About Our Research
The Jiang Laboratory studies the molecular mechanisms of RNA and DNA editing in normal and cancer stem cells, how these editase enzymes are regulated in different cellular contexts, and how to target these pathways in pre-clinical models of both solid tumor and blood malignancies. The Jiang lab is pursuing these interests by studying the functions and molecular targets of DNA/RNA editing enzymes that specify normal stem cell development and maintain cancer stem cells (CSCs) in T-cell lymphoblastic leukemia and ovarian cancer models. We employ a variety of bioinformatic, molecular and cell biological tools, as well as patient samples and xenograft mouse models to address these questions surrounding human health and disease.
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